INDUCTION OF ALVEOLAR ICAM-1 IN THE DEVELOPING LUNG ▴ 324

Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury.

Intercellular adhesion molecule-1 (ICAM-1; CD54) is an adhesion molecule constitutively expressed in abundance on the cell surface of type I alveolar epithelial cells (AEC) in the normal lung and is a critical participant in pulmonary innate immunity. At many sites, ICAM-1 is shed from the cell surface as a soluble molecule (sICAM-1). Limited information is available regarding the presence, sou...

Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation.

Intercellular adhesion molecule-1 (ICAM-1) is known to play a central role in lung inflammation. Limited information, however, is available regarding the expression and biological function of ICAM-1 in the alveolar epithelial compartment. The current report analyses the expression pattern of ICAM-1 in primary cultures of rat alveolar epithelial cells (AECs) and in the rat lung following instill...

The Effects of Amiodarone of Rabbit Lung Alveolar Cells

Purpose: The effects of Amiodarone on lung tissue and morphologic changes of alveolar cells. Materials and Methods: in this study, we used 21 mature male rabbits and they were divided into control and two experimental groups. Daily 80 mg/kg amiodarone was injected intra peritoneally to the experimental animals for one or two weeks. The control group received normal saline the same dose as amio...

THE ROLE OF ALVEOLAR MACROPHAGES IN THE PRODUCTION OF COLONY –STIMULATING FACTOR BY THE LUNG

The role of alveolar macrophages in the production of granulocyte/ macrophage colony-stimulating factor(s) by the rat lung was investigated. Lavaged lungs, when incubated at proper weight per volume of culture medium, produced the same amount of colony-stimulating factor as unlavaged ones. Both lavaged and unlavaged lungs produced similar types of colony-stimulating factor (s). Prolonged i...

Soluble ICAM-1 Activates Lung Macrophages